(1R,3S,Z)-5-((E)-2-((1S,3aS,7aS)-1-((S)-1-(3-羟基-3-甲基丁氧基)乙基)-7a-甲基六氢-1H-茚-4(2H)-亚基)亚乙基)-4-亚甲基环己烷-1,3-二醇; 马沙骨化醇 ; 玛莎骨化醇
Maxacalcitol (Synonyms: 22-Oxacalcitriol)
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中文名称(1R,3S,Z)-5-((E)-2-((1S,3aS,7aS)-1-((S)-1-(3-羟基-3-甲基丁氧基)乙基)-7a-甲基六氢-1H-茚-4(2H)-亚基)亚乙基)-4-亚甲基环己烷-1,3-二醇; 马沙骨化醇 ; 玛莎骨化醇
英文名称 Maxacalcitol (Synonyms: 22-Oxacalcitriol)
CAS号103909-75-7
分子式C26H42O4
分子量418.61
MDLMFCD00871502
外观White to off-white powder
储存条件 4°C, protect from light, stored under nitrogen
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Maxacalcitol, a vitamin D3 analog, acts as a potent orally active VDR agonist with minimal calcemic effects. It inhibits PTH mRNA expression and bone resorption, making it a promising candidate for hyperparathyroidism research. Additionally, Maxacalcitol exhibits anti-tumor activity by suppressing cell proliferation, migration, and inducing apoptosis through GPx-1 inhibition. Its unique properties suggest potential utility in treating psoriasis and underscore its significance in bone health and cancer research.

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(1R,3S,Z)-5-((E)-2-((1S,3aS,7aS)-1-((S)-1-(3-羟基-3-甲基丁氧基)乙基)-7a-甲基六氢-1H-茚-4(2H)-亚基)亚乙基)-4-亚甲基环己烷-1,3-二醇; 马沙骨化醇 ; 玛莎骨化醇