中文名称 | N-(2-氯-6-甲基苯基)-2-((6-(4-(2-羟乙基)哌嗪-1-基)-2-甲基嘧啶-4-基)氨基)噻唑-5-甲酰胺; 达沙替尼 |
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英文名称 | Dasatinib (Synonyms: BMS-354825) |
CAS号 | 302962-49-8 |
分子式 | C22H26ClN7O2S |
分子量 | 488.01 |
MDL | MFCD11046566 |
外观 | White, off-white to pale yellow powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Dasatinib is a novel, potent and multi-targeted inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM in cell-free assays, respectively. Dasatinib induces autophagy and apoptosis with anti-tumor activity.
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