| 中文名称 | (5R,5aR,8aR,9S)-9-(((2R,4aR,6R,7R,8R,8aS)-7,8-二羟基-2-(噻吩-2-基)六氢吡喃并[3,2-d][1,3]二氧杂环己烯-6-基)氧基)-5-(4-羟基-3,5-二甲氧基苯基)-5,5a,8a,9-四氢呋喃并[3',4':6,7]萘并[2,3-d][1,3]二氧杂环戊烯-6(8H)-酮; 替尼泊苷;鬼臼噻吩苷 |
|---|---|
| 英文名称 | Teniposide (Synonyms: VM26;NSC 122819;VM-26) |
| CAS号 | 29767-20-2 |
| 分子式 | C32H32O13S |
| 分子量 | 656.66 |
| MDL | MFCD00866516 |
| 外观 | White to off-white powder |
| 储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Teniposide is a semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. This agent acts in the late S or early G phase of the cell cycle.
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