二盐酸诺拉曲塞
Nolatrexed dihydrochloride
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基本信息
中文名称二盐酸诺拉曲塞
英文名称 Nolatrexed dihydrochloride
CAS号152946-68-4
分子式C14H14Cl2N4OS
分子量357.26
外观 Light yellow to yellow powder
储存条件 Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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Nolatrexed dihydrochloride (Thymitaq) is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication,  DNA damage,S-phase cell cycle arrest, and caspase-dependent apoptosis.This agent also exhibits radiosensitizing activity.


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