中文名称 | 3-甲基-4-氧代-3,4-二氢咪唑并[5,1-d][1,2,3,5]四嗪-8-甲酰胺;替莫唑胺 |
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英文名称 | Temozolomide | NSC 362856 | CCRG 81045 | TMZ |
CAS号 | 85622-93-1 |
分子式 | C6H6N6O2 |
分子量 | 194.15 |
MDL | MFCD00866492 |
外观 | Off-white crystalline powder |
储存条件 | -20°C, protect from light, stored under nitroge |
1. TMZ(Temozolomide) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. A DNA damage inducer in L-1210 and L-1210/BCNU cells. Temozolomide induces apoptosis and exhibits antitumor activity.
2.Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects.
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