中文名称 | 美登素 DM1 | 美登新 |
---|---|
英文名称 | Mertansine (Synonyms: DM1; Maytansinoid DM1) |
CAS号 | 139504-50-0 |
分子式 | C35H48ClN3O10S |
分子量 | 738.29 |
外观 | Off-white solid |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Mertansine (DM1, Maytansinoid DM1), an antibody-conjugatable maytansinoid, is a selective microtubule inhibitor that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC).Solutions are unstable and should be fresh-prepared.
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