中文名称 | (2E)-N-[4-[3-氯-4-(2-吡啶基甲氧基)苯胺基]-3-氰基-7-乙氧基-6-喹啉基]-4-(二甲氨基)-2-丁烯酰胺;来那替尼 |
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英文名称 | Neratinib (Synonyms: HKI-272) |
CAS号 | 698387-09-6 |
分子式 | C30H29ClN6O3 |
分子量 | 557.04 |
MDL | MFCD09752958 |
外观 | Pale yellow to white powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Neratinib is a highly selective inhibitor of HER2 and EGFR, demonstrating IC50 values of 59 nM and 92 nM in cell-free assays, respectively. It weakly inhibits KDR and Src, while showing no significant inhibition against Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf, and c-Met.
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