地瑞那韦 | 达芦那韦
Darunavir (Synonyms: TMC114; UIC-94017)
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200 mg 500 mg 1 g 5 g
产品库存
In-stock
目录价格
¥300.00
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In-stock
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¥450.00
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In-stock
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¥750.00
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产品库存
In-stock
目录价格
¥3000.00
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基本信息
中文名称地瑞那韦 | 达芦那韦
英文名称 Darunavir (Synonyms: TMC114; UIC-94017)
CAS号206361-99-1
分子式C₂₇H₃₇N₃O₇S
分子量547.66
外观White to off-white powder
储存条件 Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
安全信息
产品详情

Darunavir is a drug used to treat HIV infection. It is in the protease inhibitor class. Darunavir is an orally-bioavailable non-peptidic inhibitor of human immunodeficiency virus type 1 (HIV-1) protease that selectively inhibits HIV-1 protease enzyme induced cleavage of gag and gag-pol poly-proteins preventing the maturation of virions and also inhibits the dimerization of HIV-1 protease suppressing proteolytic activity and subsequent replication of HIV-1. Study results have shown that darunavir exhibits potent inhibition against HIV-1 with a value of 50% inhibition concentration IC50 of 0.003 μmol/L in HIV-1 infected MT-2 cells. Darunavir binds to HIV-1 protease with considerably high affinity and fits closely with the substrate envelop leading to its potent ability to inhibit multidrug-resistant HIV strains. Prezista is an OARAC recommended treatment option for treatment-naïve and treatment-experienced adults and adolescents.
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