乌帕替尼
ABT-494(Upadacitinib) Free base
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基本信息
中文名称乌帕替尼
英文名称 ABT-494(Upadacitinib) Free base
CAS号1310726-60-3
分子式C₁₇H₁₉F₃N₆O
分子量380.37
外观White to yellow powder
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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 Upadacitinib, also known as ABT-494, is a potent and selective JAK inhibitors in development for rheumatoid arthritis. ABT-494 is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. ABT-494 demonstrates efficacy in rat arthritis models. Preliminary evidence suggests that compared to tofacitinib, ABT-494 may spare Jak2 and Jak3 dependent signaling.

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