尼拉帕尼
Niraparib (MK-4827)
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基本信息
中文名称尼拉帕尼
英文名称 Niraparib (MK-4827)
CAS号1038915-60-4
分子式C₁₉H₂₀N₄O
分子量320.39
外观White to light yellow powder
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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Niraparib, also known as MK4827, is an orally active, potent and selective poly(ADP-Ribose) polymerase (PARP) inhibitor that radiosensitizes human lung and breast cancer cells. Niraparib inhibits PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM respectively. Niraparib is currently in Phase 3 clinical trials for ovarian cancer and BRCA+ breast cancer.

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