| 中文名称 | 布格替尼 |
|---|---|
| 英文名称 | Brigatinib | AP-26113 |
| CAS号 | 1197953-54-0 |
| 分子式 | C29H39ClN7O2P |
| 分子量 | 584.09 |
| 外观 | White to light yellow powder |
| 储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
Brigatinib is a potent and selective ALK (IC50, 0.6 nM) and ROS1 (IC50, 0.9 nM) inhibitor. It also inhibits IGF-1R, FLT3, and mutant variants of FLT3 (D835Y) and EGFR with lower potentcy.
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