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(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-二羟基-3-((R)-1-((1S,3R,4R)-4-(2-羟基乙氧基)-3-甲氧基环己基)丙-2-基)-10,21-二甲氧基-6,8,12,14,20,26-六甲基-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-十六氢-3H-23,27-环氧吡啶并[21-c][1]氧杂]4]氮杂环;依维莫司

Everolimus | RAD-001

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产品编号：CL2331

CAS No.：159351-69-6

MDLNo：MFCD00929329

分子式：C53H83NO14

分子量：958.22

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￥328.00

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产品库存

In-stock

目录价格

￥568.00

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基本信息

中文名称	(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-二羟基-3-((R)-1-((1S,3R,4R)-4-(2-羟基乙氧基)-3-甲氧基环己基)丙-2-基)-10,21-二甲氧基-6,8,12,14,20,26-六甲基-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-十六氢-3H-23,27-环氧吡啶并[21-c][1]氧杂]4]氮杂环;依维莫司
英文名称	Everolimus \| RAD-001
CAS号	159351-69-6
分子式	C53H83NO14
分子量	958.22
MDL	MFCD00929329
外观	White to off-white powder
储存条件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

安全信息

产品详情

Everolimus, also known as RAD001, is a derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties. In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production.

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(1R,2R,4R)-4-((R)-2-((3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-二羟基-10,21-二甲氧基-6,8,12,14,20,26-六甲基-1,5,1,28,29-五氧代-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-二十四氢-3H-23,27-环氧吡啶并[2,1-c][1]氧杂[4]氮杂环三十一碳烷-3-基)丙基)-2-甲氧基环己基 3-羟基-2-(羟甲基)-2-甲基丙酸酯; 替西罗莫司; 坦西莫司; 西罗莫司脂化物

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