奥巴克拉甲磺酸盐
Obatoclax mesylate (GX15-070)
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¥660.00
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基本信息
中文名称奥巴克拉甲磺酸盐
英文名称 Obatoclax mesylate (GX15-070)
CAS号803712-79-0
分子式C20H19N3O.CH4O3S
分子量413.49
外观 Purple to black powder
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Obatoclax, also known as GX 015-070, a synthetic small-molecule inhibitor of the bcl-2 family of proteins with potential pro-apoptotic and antineoplastic activities. Obatoclax binds to members of the Bcl-2 protein family, preventing the binding of these anti-apoptotic proteins to the pro-apoptotic proteins Bax and Bak and so promoting the activation of the apoptotic pathway in Bcl-2-overexpressing cells. The Bcl-2 family of proteins (bcl-2, bcl-xl, bcl-w, and Mcl-1) are overexpressed in a wide variety of cancers, including those of the lymphatic system, breast, lung, prostate, and colon.

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奥巴克拉甲磺酸盐