Navitoclax (ABT-263)
Navitoclax (ABT-263)
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¥480.00
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¥760.00
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基本信息
中文名称Navitoclax (ABT-263)
英文名称 Navitoclax (ABT-263)
CAS号923564-51-6
分子式C47H55ClF3N5O6S3
分子量974.61
外观White to light yellow powder
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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Navitoclax, also known as ABT-263, is an orally bioavailable, synthetic small-molecule antagonist of a subset of the B-cell leukemia 2 (Bcl-2) family of proteins with potential antineoplastic activity. ABT-263 selectively binds to apoptosis suppressor proteins Bcl-2, Bcl-XL, and Bcl-w and prevents their binding to the apoptotic effectors Bax and Bak proteins, which may trigger apoptosis in tumor cells overexpressing Bcl-2, Bcl-XL, and Bcl-w.

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