中文名称 | N-[(苄氧基)羰基]-L-亮氨酰-N-[(1S)-1-甲酰基-3-甲基丁基]-L-亮氨酰胺 |
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英文名称 | MG-132 (Synonyms: Z-Leu-Leu-Leu-al; MG132) |
CAS号 | 133407-82-6 |
分子式 | C26H41N3O5 |
分子量 | 475.62 |
MDL | MFCD00674886 |
外观 | White to yellow powder |
储存条件 | Store short-term at 0-4°C or long-term at -20°C in a dry, dark place. |
MG-132, a potent proteasome and calpain inhibitor, boasts IC50s of 100 nM and 1.2 μM, respectively. This peptide aldehyde effectively halts the 26S proteasome complex's proteolytic activity. Beyond its inhibitory role, MG-132 activates autophagy and triggers apoptosis. Studies reveal that MG-132 can activate autophagy in vascular smooth muscle cells, inhibiting senescence through the PI3K/AKT/mTOR pathway. It also induces apoptosis in a cell cycle-dependent manner, highlighting its multifaceted bioactivity in cellular regulation.
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