塞卡替尼
Saracatinib (AZD0530)
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In-stock
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¥466.00
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In-stock
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¥688.00
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3-5days
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¥966.00
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3-5days
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¥1668.00
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基本信息
中文名称塞卡替尼
英文名称 Saracatinib (AZD0530)
CAS号379231-04-6
分子式C27H32ClN5O5
分子量542.03
外观White to light yellow powder
储存条件 Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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 Saracatinib, also known as AZD0530, is an orally available dual-specific inhibitor of Src and Abl with anti-invasive and anti-tumor activities. Src and Abl are protein tyrosine kinases that are overexpressed in chronic myeloid leukemia cells. Saracatinib binds to and inhibits these tyrosine kinases and their effects on cell motility, cell migration, adhesion, invasion, proliferation, differentiation, and survival.

Saracatinib (AZD0530) is a potent Src family inhibitor with IC50s of 2.7 to 11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr, and Blk. Saracatinib shows high selectivity over other tyrosine kinases.


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