米哚妥林
Midostaurin (Synonyms: PKC412; CGP 41251)
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基本信息
中文名称米哚妥林
英文名称 Midostaurin (Synonyms: PKC412; CGP 41251)
CAS号120685-11-2
分子式C35H30N4O4
分子量570.64
外观White to yellow powder
储存条件-20°C, sealed storage, away from moisture
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PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platelet-derived growth factor receptor (PDGFR) and FMS-like tyrosine kinase 3 (FLT3) tyrosine kinases, which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors.
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