中文名称 | 雷帕霉素 | 西罗莫司 |
---|---|
英文名称 | Rapamycin | Sirolimus | AY-22989 | NSC-2260804 |
CAS号 | 53123-88-9 |
分子式 | C51H79NO13 |
分子量 | 914.18 |
外观 | White to off-white powder |
储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
Rapamycin is a specific mTOR inhibitor with IC50 of ~0.1 nM HEK293 cells.Rapamycin binds to FKBP12 and specifically acts as an allosteric inhibitor of mTORC1. Rapamycin is an autophagy activator and an immunosuppressant.
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