中文名称 | 康普瑞汀磷酸二钠 |
---|---|
英文名称 | Fosbretabulin Disodium (Synonyms:CA 4DP; CA 4P; Combretastatin A4 Disodium Phosphate(CA4P)) |
CAS号 | 168555-66-6 |
分子式 | C18H19PO8Na2 |
分子量 | 440.29 |
外观 | White powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Fosbretabulin (Combretastatin A4 Phosphate, CA4P, CA 4DP) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM in a cell-free assay. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. Fosbretabulin disodium induces mitotic arrest and apoptosis in endothelial cells. Phase 3.
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