CB-839
Telaglenastat (Synonyms: CB-839)
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5 mg 10 mg
产品库存
3-5days
目录价格
¥578.00
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产品库存
3-5days
目录价格
¥1088.00
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基本信息
中文名称CB-839
英文名称 Telaglenastat (Synonyms: CB-839)
CAS号1439399-58-2
分子式C26H24F3N7O3S
分子量571.57
外观Off-white to yellow powder
储存条件Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.
安全信息
产品详情

Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC50s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inuduces autophagy and has antitumor activity.
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