中文名称 | 盐酸厄洛替尼 | 埃罗替尼盐酸盐 |
---|---|
英文名称 | Erlotinib Hydrochloride (Synonyms: Erlotinib HCl; CP-358774 hydrochloride; NSC 718781 hydrochloride; OSI-774 hydrochloride; OSI-774 HCl) |
CAS号 | 183319-69-9 |
分子式 | C22H23N3O4·HCl |
分子量 | 429.90 |
外观 | White to off-white powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Erlotinib HCl (formerly OSI-744, OSI744; trade name: Tarceva), the hydrochloride salt of erlotinib, is an EGFR (epidermal growth factor receptor) inhibitor with antitumor activity. In cell-free experiments, it inhibits EGFR with an IC50 of 2 nM, and when compared to human c-Src or v-Abl, it is >1000 times more sensitive to inhibit EGFR. The FDA and other nations have authorized erlotinib, a quinazoline derivative, for the treatment of pancreatic cancer, non-small cell lung cancer (NSCLC), and various other cancer types.
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