盐酸厄洛替尼 | 埃罗替尼盐酸盐
Erlotinib Hydrochloride (Synonyms: Erlotinib HCl; CP-358774 hydrochloride; NSC 718781 hydrochloride; OSI-774 hydrochloride; OSI-774 HCl)
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基本信息
中文名称盐酸厄洛替尼 | 埃罗替尼盐酸盐
英文名称 Erlotinib Hydrochloride (Synonyms: Erlotinib HCl; CP-358774 hydrochloride; NSC 718781 hydrochloride; OSI-774 hydrochloride; OSI-774 HCl)
CAS号183319-69-9
分子式C22H23N3O4·HCl
分子量429.90
外观White to off-white powder
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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Erlotinib HCl (formerly OSI-744, OSI744; trade name: Tarceva), the hydrochloride salt of erlotinib, is an EGFR (epidermal growth factor receptor) inhibitor with antitumor activity. In cell-free experiments, it inhibits EGFR with an IC50 of 2 nM, and when compared to human c-Src or v-Abl, it is >1000 times more sensitive to inhibit EGFR. The FDA and other nations have authorized erlotinib, a quinazoline derivative, for the treatment of pancreatic cancer, non-small cell lung cancer (NSCLC), and various other cancer types.
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