中文名称 | (S)-异丙基 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-二氧代-3,4-二氢嘧啶-1(2H)-基)-4-氟-3-羟基-4-甲基四氢呋喃-2-基)甲氧基(苯氧基)磷酰基)氨基)丙酸酯; 索非布韦 ; 索氟布韦 |
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英文名称 | Sofosbuvir (Synonyms: PSI-7977; GS-7977) |
CAS号 | 1190307-88-0 |
分子式 | C22H29FN3O9P |
分子量 | 529.45 |
MDL | MFCD26523124 |
外观 | White to off-white powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Sofosbuvir, a nucleotide analog prodrug, is known for its potent inhibition of HCV NS5B polymerase. It has been optimized for bioactivity by modifying its structure to enhance cellular uptake and resistance to exonuclease proofreading.The compound is metabolized to an active triphosphate form that terminates viral RNA replication.
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