盐酸克里唑替尼
Crizotinib hydrochloride | PF-02341066 hydrochloride
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10 mg 25 mg 50 mg
产品库存
3-5days
目录价格
¥600.00
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产品库存
3-5days
目录价格
¥980.00
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产品库存
3-5days
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¥1568.00
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基本信息
中文名称盐酸克里唑替尼
英文名称 Crizotinib hydrochloride | PF-02341066 hydrochloride
CAS号1415560-69-8
分子式C21H23Cl3FN5O
分子量486.80
外观Yellow to brown powder
储存条件4°C, sealed storage, away from moisture
安全信息
产品详情

Crizotinib HCl (formerly known as PF-02341066 hydrochloride; trade name: Xalkori) is a potent, orally bioavailable small molecule inhibitor of c-Met and ALK, with IC50 values of 11 nM and 24 nM in assays involving cells, respectively. In the US, crizotinib is licensed for the treatment of non-small cell lung cancer (NSCLC). It is also being investigated in clinical trials for safety and effectiveness in the treatment of neuroblastoma, anaplastic large cell lymphoma, and other advanced solid tumors in both adults and children. Crizotinib inhibits the activation of the MET signaling pathway and the membrane receptor MET, which in susceptible tumor cell populations may prevent tumor cell growth, migration, invasion, and angiogenesis.

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盐酸克里唑替尼