| 中文名称 | N-(3-氯-4-氟苯基)-7-甲氧基-6-(3-吗啉丙氧基)喹唑啉-4-胺;吉非替尼 | 吉菲替尼 |
|---|---|
| 英文名称 | Gefitinib (Synonyms: ZD1839; N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine) |
| CAS号 | 184475-35-2 |
| 分子式 | C22H24ClFN4O3 |
| 分子量 | 446.90 |
| 外观 | White to off-white powder |
| 储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy and cell apoptosis, which can be used for cancer related research, such as Lung cancer and breast cancer.
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