Linsitinib (OSI-906)
Linsitinib (OSI-906)
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产品库存
3-5days
目录价格
¥500.00
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产品库存
3-5days
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¥980.00
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产品库存
3-5days
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¥1600.00
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基本信息
中文名称Linsitinib (OSI-906)
英文名称 Linsitinib (OSI-906)
CAS号867160-71-2
分子式C26H23N5O
分子量421.49
外观White to yellow powder
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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产品详情

Linsitinib (formerly OSI-906; OSI 906) is a firs-in-class, ATP-competitive and orally bioavailable dual inhibitor of and insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF-1R) with potential antitumor activity. It exhibits modest potency against InsR with an IC50 of 75 nM, and it has no activity against other kinases like Abl, ALK, BTK, EGFR, FGFR1/2, PKA, and so on. In cell-free assays, it inhibits IGF-1R with an IC50 of 35 nM.

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