2-[(2-氯-4-碘苯基)氨基]-N-(环丙基甲氧基)-3,4-二氟-苯甲酰胺
PD184352(Synonyms: CI-1040)
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5 mg 10 mg 25 mg
产品库存
3-5days
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¥400.00
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产品库存
3-5days
目录价格
¥650.00
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产品库存
3-5days
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¥1160.00
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基本信息
中文名称2-[(2-氯-4-碘苯基)氨基]-N-(环丙基甲氧基)-3,4-二氟-苯甲酰胺
英文名称 PD184352(Synonyms: CI-1040)
CAS号212631-79-3
分子式C17H14ClF2 IN2O2
分子量478.66
MDLMFCD02683961
外观White to off-white powder
储存条件 Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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产品详情

PD184352 (PD-184352; CI-1040), an analog of benzhydroxamate, is an orally bioactive, specific, allosteric/non-ATP competitive MEK1/2 inhibitor with potential anticancer activity. In cell-based assays, it inhibits MEK1/2 with IC50 values of 17 nM and exhibits a 100-fold preference for MEK1/2 over MEK5. In mouse xenograft models, it exhibits strong in vitro anti-proliferative activity and significant in vivo antitumor efficacy.

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2-[(2-氯-4-碘苯基)氨基]-N-(环丙基甲氧基)-3,4-二氟-苯甲酰胺
LM-41