中文名称 | PHA-543613 |
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英文名称 | PHA-543613 |
CAS号 | 478149-53-0 |
分子式 | C15H17N3O2 |
分子量 | 271.31 |
外观 | White to off-white powder |
PHA-543613 is a potent, orally bioactive, BBB (blood-brain barrier)-crossing, and selective α7 nAChR agonist with Ki of 8.8 nM. PHA-543613 is more selective for α7-nAChR than α3β4, α1β1γδ, α4β2 and 5-HT3 receptors. PHA-543613 may be used to study cognitive deficits in Alzheimer's disease (AD) and schizophrenia.
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