9-(6-氨基吡啶-3-基)-1-(3-(三氟甲基)苯基)苯并[H][1,6]萘啶-2(1H)-酮
Torin 2
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产品库存
3-5days
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¥620.00
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产品库存
3-5days
目录价格
¥950.00
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产品库存
3-5days
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¥1660.00
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基本信息
中文名称9-(6-氨基吡啶-3-基)-1-(3-(三氟甲基)苯基)苯并[H][1,6]萘啶-2(1H)-酮
英文名称 Torin 2
CAS号1223001-51-1
分子式C24H15F3N4O
分子量432.40
外观White to light yellow powder
储存条件 Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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产品详情

Torin-2 is a novel, second-generation ATP-competitive inhibitor that is potent and selective for mTOR with a superior pharmacokinetic profile to previous inhibitors ((EC50 = 0.3 nM). It has been shown that Torin-2 displayed dramatic antiproliferative activity across a panel of cancer cell lines. Torin-2 showed a powerful cytotoxic activity, inhibiting the growth of each cell line in a dose-dependent manner, with an IC₅₀ in the nanomolar range. Torin-2 caused both apoptosis and autophagy, induced cell cycle arrest in G₀/G₁ phase and affected both mTORC1 and mTORC2 activities.

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NVP-AEW541 (AEW541)
9-(6-氨基吡啶-3-基)-1-(3-(三氟甲基)苯基)苯并[H][1,6]萘啶-2(1H)-酮