中文名称 | 9-(6-氨基吡啶-3-基)-1-(3-(三氟甲基)苯基)苯并[H][1,6]萘啶-2(1H)-酮 |
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英文名称 | Torin 2 |
CAS号 | 1223001-51-1 |
分子式 | C24H15F3N4O |
分子量 | 432.40 |
外观 | White to light yellow powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Torin-2 is a novel, second-generation ATP-competitive inhibitor that is potent and selective for mTOR with a superior pharmacokinetic profile to previous inhibitors ((EC50 = 0.3 nM). It has been shown that Torin-2 displayed dramatic antiproliferative activity across a panel of cancer cell lines. Torin-2 showed a powerful cytotoxic activity, inhibiting the growth of each cell line in a dose-dependent manner, with an IC₅₀ in the nanomolar range. Torin-2 caused both apoptosis and autophagy, induced cell cycle arrest in G₀/G₁ phase and affected both mTORC1 and mTORC2 activities.
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