中文名称 | 奥拉替尼马来酸盐 (1208319-27-0) |
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英文名称 | Oclacitinib Maleate (PF-03394197 Maleate) |
CAS号 | 1640292-55-2 |
分子式 | C19H27N5O6S |
分子量 | 453.51 |
外观 | White to off-white powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Oclacitinib maleate (formerly PF-03394197 maleate) is a novel and potent inhibitor of JAK (Janus kinase) family members with IC50 values ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM. Oclacitinib did not inhibit a panel of 38 non-JAK kinases and is the most potent at inhibiting JAK1. Oclacitinib also inhibits the function of JAK1-dependent cytokines involved in allergy and inflammation as well as pruritus. Cclacitinib is a targeted therapy that selectively inhibits JAK1-dependent cytokines involved in allergy, inflammation, and pruritus and suggests these are the mechanisms by which oclacitinib effectively controls clinical signs associated with allergic skin disease in dogs.
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