奥拉替尼马来酸盐 | 奥克拉西替尼 (1208319-27-0)
Oclacitinib Maleate (Synonyms: Oclacitinib monomaleate; PF-03394197 monomaleate;PF-03394197 Maleate)
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5 mg 10 mg 25 mg
产品库存
3-5days
目录价格
¥650.00
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产品库存
3-5days
目录价格
¥975.00
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产品库存
3-5days
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¥1800.00
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基本信息
中文名称奥拉替尼马来酸盐 | 奥克拉西替尼 (1208319-27-0)
英文名称 Oclacitinib Maleate (Synonyms: Oclacitinib monomaleate; PF-03394197 monomaleate;PF-03394197 Maleate)
CAS号1640292-55-2
分子式C19H27N5O6S
分子量453.51
外观White to off-white powder
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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产品详情

Oclacitinib maleate (formerly PF-03394197 maleate) is a novel and potent inhibitor of JAK (Janus kinase) family members with IC50 values ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM. Oclacitinib did not inhibit a panel of 38 non-JAK kinases and is the most potent at inhibiting JAK1. Oclacitinib also inhibits the function of JAK1-dependent cytokines involved in allergy and inflammation as well as pruritus. Cclacitinib is a targeted therapy that selectively inhibits JAK1-dependent cytokines involved in allergy, inflammation, and pruritus and suggests these are the mechanisms by which oclacitinib effectively controls clinical signs associated with allergic skin disease in dogs.
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