Rebastinib (DCC-2036)
Rebastinib (DCC-2036)
ChemLeader
产品编号:
CAS No.:
MDLNo:
分子式:
分子量:
选择规格
5 mg 10 mg 25 mg
产品库存
3-5days
目录价格
¥620.00
会员价格
产品库存
3-5days
目录价格
¥1000.00
会员价格
产品库存
3-5days
目录价格
¥1800.00
会员价格
选择数量
- +
基本信息
中文名称Rebastinib (DCC-2036)
英文名称 Rebastinib (DCC-2036)
CAS号1020172-07-9
分子式C30H28FN7O3
分子量553.59
外观White to off-white powder
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
安全信息
产品详情

Rebastinib (formerly also known as DCC-2036), a novel, potent and orally bioavailable small-molecule inhibitor of multiple tyrosine kinases with potential antineoplastic activity, is a conformational control Bcr-Abl inhibitor for Abl1(WT) and Abl1(T315I) with IC50s of 0.8 nM and 4 nM. It also inhibits other kinases such as SRC, LYN, FGR, HCK, KDR, FLT3, and Tie-2, and has low activity towards c-Kit. DCC-2036 inhibits ABL1 through forcing the kinase domains into inhibitor-bound, inactive Type II conformations. In cellular assay, DCC-2036 inhibits the proliferation of Ba/F3 and K562 cells with IC50 values of 5.4nM and 5.5nM, respectively.

相关文献
相关产品
抱歉,暂时没有相关产品
浏览记录
Rebastinib (DCC-2036)
玛格妥昔单抗