中文名称 | 奈拉滨 |
---|---|
英文名称 | Nelarabine | 506U78 | GW 506U78 | Arranon |
CAS号 | 121032-29-9 |
分子式 | C11H15N5O5 |
分子量 | 297.27 |
外观 | White to off-white powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Nelarabine (formerly 506 U78; GW-506U78; NS-686673; 506U78, GW506U78; Atriance; Arranon; Nelzarabine) is a cytotoxic/chemotherapeutic medication approved for use in the treatment of hematological malignancies (T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma). It is an analog of purine nucleosides that inhibits DNA synthesis in tumor cells, with an IC50 ranging from 0.067 to 2.15 μM.
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