中文名称 | 醋酸卡泊芬净; 二醋酸卡泊芬净 |
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英文名称 | Caspofungin diacetate (Synonyms: MK-0991 diacetate; L-743872 diacetate;Caspofungin Acetate) |
CAS号 | 179463-17-3 |
分子式 | C56H96N10O19 |
分子量 | 1,213.42 |
外观 | White to off-white powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Caspofungin acetate (formerly known as MK-0991), a cyclic lipopeptide, is a new class of antifungal drug. It is a semi-synthetic analogue of pneumocandin B0 with improved water solubility, a significant limitation in the development of the echinocandin class as pharmaceuticals. Caspofungin acts by inhibiting the synthesis of β (1,3)-D-glucan, an essential component of the cell wall of susceptible fungi. Incubation ofA. fumigatuwith a single dose of caspofungin affected the same proportion of apical and subapical branching cells for up to 72 h.The cells at the active centers for new cell wall synthesis withinA. fumigateshyphae are killed when they are exposed to caspofungin.
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