Sotuletinib (BLZ945)
Sotuletinib (BLZ945)
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产品编号:
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选择规格
5 mg 10 mg 25 mg
产品库存
3-5days
目录价格
¥600.00
会员价格
产品库存
3-5days
目录价格
¥900.00
会员价格
产品库存
3-5days
目录价格
¥1600.00
会员价格
选择数量
- +
基本信息
中文名称Sotuletinib (BLZ945)
英文名称 Sotuletinib (BLZ945)
CAS号953769-46-5
分子式C20H22N4O3S
分子量398.48
外观Off-white to light brown powder
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
安全信息
产品详情

Sotuletinib (formerly BLZ945; BLZ-945) is a novel, potent, selective, orally bioactive, and brain-penetrant CSF-1R (colony stimulating factor 1 receptor) inhibitor with potential antitumor activity. It exhibits 1000-fold higher selectivity against its closest receptor tyrosine kinase homologs and inhibits CSF-1R with an IC50 of 1 nM. Glioma-bearing mice demonstrate high in vivo antitumor efficaciousness of BLZ945. Sotuletinib was designated as an orphan drug by the US FDA in August 2022 in order to treat patients suffering from Amyotrophic Lateral Sclerosis (ALS), a progressive neurological disorder that affects nerve cells in the brain and spinal cord and results in loss of motor control.

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