奥当卡替
Odanacatib (Synonyms: MK-0822)
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1 mg 5 mg
产品库存
3-5days
目录价格
¥1900.00
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产品库存
3-5days
目录价格
¥4180.00
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基本信息
中文名称奥当卡替
英文名称 Odanacatib (Synonyms: MK-0822)
CAS号603139-19-1
分子式C25H27F4N3O3S
分子量525.56
外观White to brown powder
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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产品详情

Odanacatib (MK-0822) is a potent, neutral, and selective inhibitor of human/rabbit cathepsin K that may be applied to the management of bone metastases and osteoporosis. With IC50s of 0.2 nM/1 nM, it inhibits cathepsin K (human/rabbit) and shows good selectivity against off-target cathepsins B, L, and S. Odanacatib binds to cathepsin K specifically and inhibits its activity. This may reduce bone resorption, improve bone mineral density, and reverse osteoporotic changes. Approximately 16,000 postmenopausal osteoporosis patients are participating in a phase III trial to assess the potential of odanacatib to reduce fracture risk.
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