噁拉戈利
Elagolix (NBI-56418)
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1 mg 5 mg 10 mg
产品库存
3-5days
目录价格
¥320.00
会员价格
产品库存
3-5days
目录价格
¥860.00
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产品库存
3-5days
目录价格
¥1350.00
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基本信息
中文名称噁拉戈利
英文名称 Elagolix (NBI-56418)
CAS号834153-87-6
分子式C32H30F5N3O5
分子量631.59
外观White to off-white powder
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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产品详情

Elagolix (formerly NBI56418; ABT620; NBI-56418; ABT-620; trade name: Orilissa) is a potent, specific, orally bioavailable, non-peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) used for pain management. It inhibits GnRHR with a Kd of 54 pM. Elagolix was given FDA approval on July 23, 2018, to treat endometriosis-related moderate to severe pain. A short-acting GnRH antagonist, elagolix suppresses ovarian estrogen production in a dose-dependent manner, resulting in partial suppression at lower doses and complete suppression at higher doses. Because Elagolix is non-peptide and readily absorbed through the mouth, it is considered the leader of a new class of GnRH inhibitors known as second-generation inhibitors.

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