7-氨基-1-环丙基-3-乙基-2,4-二氧代-1,2,3,4-四氢吡啶并[2,3-d]嘧啶-6-甲酰胺
A-484954; 7-Amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide
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中文名称7-氨基-1-环丙基-3-乙基-2,4-二氧代-1,2,3,4-四氢吡啶并[2,3-d]嘧啶-6-甲酰胺
英文名称 A-484954; 7-Amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide
CAS号142557-61-7
分子式C13H15N5O3
分子量289.29
MDLMFCD22683836
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A-484954 is a highly selective eukaryotic elongationfactor-2 kinase(eEF2K) inhibitor, with an IC50 of 280 nM.
A cell-permeable pyrido-pyrimidinedione derivative that acts as a highly potent and selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50= 280 nM). Exhibits very little activity against a broad panel of serine/threonine and protein tyrosine kinases. Inhibits eEF2 phosphorylation in multiple cell lines tested without affecting the net eEF2 levels. At concentration where it inhibits eEF2K activity, it has no effect on the proliferation of cancer cell lines.

Keywords: buy A-484954 | A-484954 supplier | purchase A-484954 | A-484954 cost | A-484954 manufacturer | order A-484954 | A-484954 distributor |  Eukaryotic elongation factor-2 kinase inhibitor |  eEF2K Inhibitor

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7-氨基-1-环丙基-3-乙基-2,4-二氧代-1,2,3,4-四氢吡啶并[2,3-d]嘧啶-6-甲酰胺