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7-氨基-1-环丙基-3-乙基-2,4-二氧代-1,2,3,4-四氢吡啶并[2,3-d]嘧啶-6-甲酰胺

A-484954 (Synonyms: 7-Amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide)

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产品编号：CL2604

CAS No.：142557-61-7

MDLNo：MFCD22683836

分子式：C13H15N5O3

分子量：289.29

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基本信息

中文名称	7-氨基-1-环丙基-3-乙基-2,4-二氧代-1,2,3,4-四氢吡啶并[2,3-d]嘧啶-6-甲酰胺
英文名称	A-484954 (Synonyms: 7-Amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide)
CAS号	142557-61-7
分子式	C13H15N5O3
分子量	289.29
MDL	MFCD22683836
外观	White to off-white solid

安全信息

产品详情

A-484954 is a highly selective eukaryotic elongationfactor-2 kinase(eEF2K) inhibitor, with an IC₅₀ of 280 nM.
A cell-permeable pyrido-pyrimidinedione derivative that acts as a highly potent and selective inhibitor of eukaryotic elongation factor-2 kinase (eEF2K) (IC50= 280 nM). Exhibits very little activity against a broad panel of serine/threonine and protein tyrosine kinases. Inhibits eEF2 phosphorylation in multiple cell lines tested without affecting the net eEF2 levels. At concentration where it inhibits eEF2K activity, it has no effect on the proliferation of cancer cell lines.
Keywords: buy A-484954 | A-484954 supplier | purchase A-484954 | A-484954 cost | A-484954 manufacturer | order A-484954 | A-484954 distributor | Eukaryotic elongation factor-2 kinase inhibitor | eEF2K Inhibitor

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