依伏磷酰胺 | 艾伏磷酰胺
Evofosfamide (Synonyms: TH-302)
ChemLeader
产品编号:
CAS No.:
MDLNo:
分子式:
分子量:
选择规格
选择数量
- +
基本信息
中文名称依伏磷酰胺 | 艾伏磷酰胺
英文名称 Evofosfamide (Synonyms: TH-302)
CAS号918633-87-1
分子式C9H16Br2N5O4P
分子量449.04
外观White to yellow powder
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
安全信息
产品详情

Evofosfamide (TH-302) is potent and selective that has an IC50 of 19 nM. It exhibits 270-fold increased cytotoxicity under hypoxia compared to their potency under aerobic conditions and is stable to cytochrome P450 metabolism. Under hypoxia, TH-302 is selectively potent and liver microsomes tolerate it well. With a high hypoxic selectivity [Hypoxia cytotoxicity ratio (HCR) = 270], replacing the chlorine with bromine in the phosphorus mustard in 3b results in a 10-fold increase in potency. Under N2, TH-302 exhibits strong cytotoxicity against human lung cancer H460 cells and human colon cancer HT29 cells. With an IC90 of 0.1 μM and 0.2 μM, respectively, TH-302 inhibits HT29 cells and H460 cells.
Tags: buy Evofosfamide (TH-302) | Evofosfamide (TH-302) supplier | purchase Evofosfamide (TH-302) | Evofosfamide (TH-302) cost | Evofosfamide (TH-302) manufacturer | order Evofosfamide (TH-302) | Evofosfamide (TH-302) distributor

相关文献
相关产品
抱歉,暂时没有相关产品
浏览记录
磷霉素左磷右胺盐
依伏磷酰胺 | 艾伏磷酰胺
重组人白介素 4(rHuIL-4)
1-(4-(3-氨基-1H-吲唑-4-基)苯基)-3-(2-氟-5-甲基苯基)脲; 利尼伐尼
SNS-314
GW 501516 | GW 1516 | GSK-516 | GW-501516 | Cardarine
N-(2-氯-4-(三氟甲基)苯基)-2-(2-(3,6-二氢-2H-吡喃-4-基)-5-乙基-6-(4-(5-羟基-6-甲基嘧啶-4-羰基)哌嗪-1-基)-7-氧代-[1,2,4]三唑并[1,5-a]嘧啶-4(7H)-基)乙酰胺钠盐
比卡格韦钠
3-氨基丙酰氮杂二苯基环辛炔; 氮杂二苯并环辛炔胺
4-(2-(4-苄基哌啶-1-基)-1-羟丙基)苯酚 半((2R,3R)-2,3-二羟基丁二酸)