特司林
Tesirine | SG3249
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产品库存
3-5days
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¥21660.00
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3-5days
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¥46360.00
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基本信息
中文名称特司林
英文名称 Tesirine | SG3249
CAS号1595275-62-9
分子式C75H101N9O23
分子量1496.65
外观 White to light yellow powder
储存条件Avoid light, nitrogen, -20 ℃
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产品详情

Tesirine (SG-3249; SG3249), cathepsin B-cleavable valine-alanine pyrrolobenzodiazepine (PBD) dimer used as an antibody-drug conjugate (ADC) payload; Tesirine was designed to combine the potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. Rovalpituzumab tesirine is a first-in-class ADC directed against delta-like protein 3 (DLL3), a novel target identified in tumour-initiating cells and expressed in small-cell lung cancer.

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特司林