中文名称 | PXL770 |
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英文名称 | PXL770 |
CAS号 | 1523493-53-9 |
分子式 | C23H18ClNO3S |
分子量 | 423.91 |
外观 | White to off-white powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
PXL770 is a novel orally bioavailable, small-molecule direct AMPK activator with EC50 of 16.2, 42.1 and 64 nM for α1β1γ1, α1β1γ2 and α1β1γ3, directly increases AMPK activity by both allosteric activation and protection from dephosphorylation. PXL770 can be used in the study of non-alcoholic fatty liver disease (NAFLD).
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