中文名称 | (S)-2-(6-(4-氯苯基)-8-甲氧基-1-甲基-4H-苯并[f][1,2,4]三唑[4,3-a][1,4]二氮杂卓-4-基)-N-乙基乙酰胺 |I-BET762 | GSK525762 | GSK525762A |
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英文名称 | Molibresib (Synonyms: I-BET762; GSK525762; GSK525762A;I-BET-762) |
CAS号 | 1260907-17-2 |
分子式 | C22H22ClN5O2 |
分子量 | 423.90 |
MDL | MFCD22417091 |
外观 | Off-white to yellow powder |
储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
Molibresib (I-BET-762, GSK525762, GSK525762A) is an inhibitor for BET proteins with IC50 of ~35 nM in a cell-free assay, suppresses the production of proinflammatory proteins by macrophages and blocks acute inflammation, highly selective over other bromodomain-containing proteins.
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