(S)-2-(6-(4-氯苯基)-8-甲氧基-1-甲基-4H-苯并[f][1,2,4]三唑[4,3-a][1,4]二氮杂卓-4-基)-N-乙基乙酰胺 |I-BET762 | GSK525762 | GSK525762A
Molibresib (Synonyms: I-BET762; GSK525762; GSK525762A;I-BET-762)
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中文名称(S)-2-(6-(4-氯苯基)-8-甲氧基-1-甲基-4H-苯并[f][1,2,4]三唑[4,3-a][1,4]二氮杂卓-4-基)-N-乙基乙酰胺 |I-BET762 | GSK525762 | GSK525762A
英文名称 Molibresib (Synonyms: I-BET762; GSK525762; GSK525762A;I-BET-762)
CAS号1260907-17-2
分子式C22H22ClN5O2
分子量423.90
MDLMFCD22417091
外观Off-white to yellow powder
储存条件Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.
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Molibresib (I-BET-762, GSK525762, GSK525762A) is an inhibitor for BET proteins with IC50 of ~35 nM in a cell-free assay, suppresses the production of proinflammatory proteins by macrophages and blocks acute inflammation, highly selective over other bromodomain-containing proteins.
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GSK 525762C | I-BET 762 besylate
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(S)-2-(6-(4-氯苯基)-8-甲氧基-1-甲基-4H-苯并[f][1,2,4]三唑[4,3-a][1,4]二氮杂卓-4-基)-N-乙基乙酰胺 |I-BET762 | GSK525762 | GSK525762A