BIX-01294
BIX-01294
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基本信息
中文名称BIX-01294
英文名称 BIX-01294
CAS号935693-62-2
分子式C28H38N6O2
分子量490.64
外观White to off-white powder
储存条件Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4℃, long-term (months to years) storage at -20 ℃.
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产品详情

BIX-01294 is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC50s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294, a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy. BIX-01294 has antitumor activity in recurrent tumor cells。


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