中文名称 | BIX-01294三盐酸盐 |
---|---|
英文名称 | BIX-01294 trihydrochloride | BIX01294 triHCl |
CAS号 | 1392399-03-9 |
分子式 | C28H41Cl3N6O2 |
分子量 | 600.02 |
储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM in a cell-free assay, reduces H3K9me2 of bulk histones, also weakly inhibits GLP (primarily H3K9me3), no significant activity observed at other histone methyltransferases. BIX01294 induces autophagy. BIX01294 also inhibits H3K36 methylation by oncoproteins NSD1, NSD2 and NSD3.
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