BIX-01294三盐酸盐
BIX-01294 trihydrochloride | BIX01294 triHCl
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基本信息
中文名称BIX-01294三盐酸盐
英文名称 BIX-01294 trihydrochloride | BIX01294 triHCl
CAS号1392399-03-9
分子式C28H41Cl3N6O2
分子量600.02
储存条件Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.
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BIX01294 is an inhibitor of G9a histone methyltransferase with IC50 of 2.7 μM in a cell-free assay, reduces H3K9me2 of bulk histones, also weakly inhibits GLP (primarily H3K9me3), no significant activity observed at other histone methyltransferases. BIX01294 induces autophagy. BIX01294 also inhibits H3K36 methylation by oncoproteins NSD1, NSD2 and NSD3.


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BIX-01294三盐酸盐