RMC-6236 | RAS-IN-2
RMC-6236 (Synonyms: RAS-IN-2)
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产品库存
3-5 days
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¥2366.00
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3-5 days
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¥5788.00
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3-5 days
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¥9388.00
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基本信息
中文名称RMC-6236 | RAS-IN-2
英文名称 RMC-6236 (Synonyms: RAS-IN-2)
CAS号2765081-21-6
分子式C43H56N8O5S
分子量797.02
外观White to off-white powder
储存条件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
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RMC-6236 is a RAS(ON)MULTI inhibitor with anticancer activity and is used in the study of advanced malignant solid tumors and colorectal cancer.
RMC-6236 is an orally active, non-covalent RAS (ON) inhibitor. RMC-6236 disrupts the interaction of wild-type or mutant RAS proteins with the RAS binding domain of BRAF, with EC50 values ranging from 28-220 nM for wild-type KRAS, NRAS, HRAS, and multiple oncogenic RAS variants. RMC-6236 inhibits pERK. RMC-6236 has anti-tumor activity against KRAS mutant tumors.
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相关文献
PMID: 38593348 PMCID: PMC11149917 DOI: 10.1158/2159-8290.CD-24-0027
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