中文名称 | 塞曲司特 | 西拉达司 |
---|---|
英文名称 | Seratrodast | AA-2414 | ABT-001 | Abbott-73001 |
CAS号 | 112665-43-7 |
分子式 | C22H26O4 |
分子量 | 354.44 |
外观 | Yellow to orange powder |
储存条件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Seratrodast (AA 2414), an orally active antiasthmatic agent, is a thromboxane A2 receptor (TP) antagonist and ferroptosis inhibitor. Seratrodast reduces lipid ROS production, modulates the systemic xc-/GSH/GPX4 axis, and inhibits JNK phosphorylation and p53 expression. Seratrodast exhibits anti-asthmatic and anti-epileptic activity.
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