中文名称 | GNE-9815 |
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英文名称 | GNE-9815 |
CAS号 | 2729996-45-4 |
分子式 | C26H22FN5O2 |
分子量 | 455.48 |
外观 | Off-white to light yellow powder |
储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
GNE-9815 (compound 7) is a highly selective, orally bioavailable pan-RAF inhibitor. For CRAF and BRAF, respectively, GNE-9815 displays Ki values of 0.062 and 0.19 nM. The MAPK pathway is modulated synergistically when GNE-9815 and the MEK inhibitor Cobimetinib are combined. Cancers with the KRAS mutation can be studied using GNE-9815.
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