中文名称 | Cilofexor(GS-9674) |
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英文名称 | Cilofexor(GS-9674) |
CAS号 | 1418274-28-8 |
分子式 | C28H22Cl3N3O5 |
分子量 | 586.85 |
外观 | Off-white to light yellow powder |
储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
Cilofexor, formerly known as GS-9674, is a farnesoid X receptor (FXR) agonist. The nonsteroidal FXR agonist cilofexor (GS-9674) improves markers of cholestasis and liver injury in patients with PSC. In clinical study, cilofexor was well tolerated and led to significant improvements in liver biochemistries and markers of cholestasis in patients with PSC.
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