Cilofexor(GS-9674)
Cilofexor(GS-9674)
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基本信息
中文名称Cilofexor(GS-9674)
英文名称 Cilofexor(GS-9674)
CAS号1418274-28-8
分子式C28H22Cl3N3O5
分子量586.85
外观Off-white to light yellow powder
储存条件Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.
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Cilofexor, formerly known as GS-9674, is a farnesoid X receptor (FXR) agonist. The nonsteroidal FXR agonist cilofexor (GS-9674) improves markers of cholestasis and liver injury in patients with PSC. In clinical study, cilofexor was well tolerated and led to significant improvements in liver biochemistries and markers of cholestasis in patients with PSC.

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