中文名称 | 波塞替尼 | HM71224 | LY3337641 | 酪氨酸蛋白激酶 BTK 抑制剂 |
---|---|
英文名称 | Poseltinib | HM71224 | LY3337641 |
CAS号 | 1353552-97-2 |
分子式 | C26H26N6O3 |
分子量 | 470.52 |
外观 | Light yellow to yellow powder |
Poseltinib (HM71224) is an orally active, selective, irreversible small molecule Bruton tyrosine kinase (BTK) inhibitor. With an IC50 of 1.95 nM. Poseltinib effectively inhibits the signaling mediated by B cell receptors (BCR), Fc receptors (FcR), and Toll-like receptors (TLR). Poseltinib has anti-inflammatory activity and can be used in the research of rheumatoid arthritis.
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