中文名称 | T0070907 |
---|---|
英文名称 | T0070907 |
CAS号 | 313516-66-4 |
分子式 | C12H8ClN3O3 |
分子量 | 277.66 |
外观 | White to light yellow powder |
储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
T0070907 is a potent inhibitor of PPARγ (peroxisome proliferator activator receptor γ ) that induces G2/M arrest and enhances the effect of radiation in human cervical cancer cells through mitotic catastrophe. It also acts as an antagonist of PPARγ that suppresses breast cancer cell proliferation and motility via both PPARgamma-dependent and -independent mechanisms.T0070907 is a potent PPARγ antagonist with a Ki of 1 nM.
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