中文名称 | 特拉匹韦 | 特拉普韦 | VX-950 |
---|---|
英文名称 | Telaprevir | VX-950 | LY-570310 | MP-424 |
CAS号 | 402957-28-2 |
分子式 | C36H53N7O6 |
分子量 | 679.85 |
外观 | White to off-white powder |
储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
Telaprevir (VX-950) is a highly selective, reversible, and potent peptidomimetic inhibitor of the HCV NS3-4A protease, the steady-state inhibitory constant (Ki) of Telaprevir is 7 nM against a genotype 1 (H strain) NS3 protease domain plus a NS4A cofactor peptide. Telaprevir inhibits SARS-CoV-2 3CLpro activity.
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