中文名称 | TG101209 |
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英文名称 | TG101209 |
CAS号 | 936091-14-4 |
分子式 | C26H35N7O2S |
分子量 | 509.67 |
外观 | White to gray powder |
储存条件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃. |
TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET (c-RET) with IC50 of 25 nM and 17 nM in cell-free assays, ~30-fold selective for JAK2 than JAK3, sensitive to JAK2V617F and MPLW515L/K mutations.
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